About the Role

　　6000! That's the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

　　We are seeking a highly talented and motivated Associate Director level structural biologist to join the Structural and Biophysical Chemistry group (SBC) at NIBR in Emeryville. We are a multidisciplinary team with expertise in X-ray crystallography, Cryo EM, NMR, and biophysics. Our team supports local efforts and collaborates with scientists across NIBR at the frontiers of chemical biology, data sciences, and disease biology to identify opportunities for next generation therapeutics. Our goal is to identify and develop small molecules for multiple therapeutic areas including cardiovascular, immunology, neuroscience, solid tumors, hematology, and global health.

　　The Associate Director will be an integral member of structure-based drug discovery teams, providing leadership and expertise to advance early drug discovery efforts, design and conduct innovative experiments to solve key scientific questions, communicate effectively and efficiently in team meetings, and collaboratively work with other scientists to develop innovative medicines. This role will impact our local discovery efforts and the global discovery portfolio through both leadership and bench-level contributions.

　　Key responsibilities:

　　• Independently design, develop, and implement crystallographic and other structural biology techniques to support the Structure-based Drug Discovery efforts at Novartis. Analyze interpret and communicate results to the project teams

　　• Collaborate with members of the Molecular Discovery, CADD, and Medicinal Chemistry groups to enable successful SBDD. Collaborate with interdisciplinary project teams globally to optimally drive the NIBR portfolio

　　• Conceptualize, establish, and lead research projects to completion, including long-range project/program goals

　　• Identify innovations in structural methods for drug discovery. Apply additional methods (e.g., biochemical, biophysical, or other analytical method) for early-stage discovery programs.

　　• Provide feedback on issues of department strategy, management, and staff performance

　　• Mentor/coach direct reports and other members of the SBC group in best practices and career development

　　• Be part of the local and global NIBR community by supporting our Curious, Inspired and Unbossed culture at Novartis

　　The pay range for this position at commencement of employment is expected to be between $166,400 and $249,600 however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

　　Diversity & Inclusion / EEO

　　The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

　　Role Requirements

　　What you'll bring to the role:

　　• Doctorate degree with 8+ years of experience in Structural Biology in an industrial setting

　　• Experience in managing and developing scientists

　　• Extensive experience in protein structural biology including construct design, protein expression, purification, characterization, crystallization, data collection, structure determination, and analysis.

　　• Experience in determining the structure of ligand-bound protein complexes and large macromolecular complexes

　　• Experience with crystallographic instrumentation (e.g., Rock Imager, Mosquito, Dragonfly, Formulator, etc.) and crystallographic software (e.g., XDS, CCP4, Phenix, Buster, Coot, etc.)

　　• Excellent written and oral communication skills

　　• Deep knowledge of structural biology and its application in drug discovery as evidenced by authorships in high-profile publications

　　• Ability to work efficiently with dynamic and interdisciplinary teams

　　Preferred qualifications:

　　• Experience with single particle cryo-EM, including sample preparation, data collection, processing, and three-dimensional reconstruction.

　　• Expertise in determining the structure of RNA and/or DNA bound, protein complexes

　　• Experience with screening strategies including fragment-based drug discovery, High-throughput screening (HTS), and DNA-encoded library (DEL) technologies

　　• Experience with other biochemical and/or biophysical assays, including SPR, ITC, and DSF.

　　• Working knowledge of protein and ligand-observe Bio-NMR techniques

　　Why Novartis?

　　766 million lives were touched by Novartis medicines in 2021, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives.

　　We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

　　We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

　　Imagine what you could do here at Novartis!

　　Commitment to Diversity & Inclusion:

　　Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

　　Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

　　Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

　　Division

　　Biomedical Research

　　Business Unit

　　Global Discovery Chemistry

　　Location

　　USA

　　Site

　　Emeryville, CA

　　Company / Legal Entity

　　NIBRI

　　Functional Area

　　Research & Development

　　Job Type

　　Full Time

　　Employment Type

　　Regular

　　Shift Work

　　No